Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Richter, Benjamin; A. Sliter, Danielle; Herhaus, Lina; Stolz, Alexandra; Wang, Chunxin; Beli, Petra; Zaffagnini, Gabriele; Wild, Philipp; Martens, Sascha; A. Wagner, Sebastian; J. Youle, Richard; Dikic, Ivan

doi:10.1073/pnas.1523926113

Public

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Shared by NobleBlocks on Mar 28, 2016 • 12:00 AM UTC

Authors:

Benjamin Richter

Danielle A. Sliter

Lina Herhaus

Abstract

Significance Selective autophagy of damaged mitochondria (mitophagy) requires protein kinases PINK1 and TBK1, ubiquitin ligase Parkin, and autophagy receptors such as OPTN, driving ubiquitin-labeled mitochondria into autophagosomes. Because all proteins have been genetically linked to either Parkins...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!