A Preliminary Trial of Lamivudine for Chronic Hepatitis B Infection

L. Dienstag, Jules; P. Perrillo, Robert; R. Schiff, Eugene; Bartholomew, Maria; Vicary, Catherine; Rubin, Marc

doi:10.1056/nejm199512213332501

Public

A Preliminary Trial of Lamivudine for Chronic Hepatitis B Infection

Published in New England Journal of Medicine • Dec 21, 1995

Authors:

Jules L. Dienstag

Robert P. Perrillo

Eugene R. Schiff

Abstract

BACKGROUND: Better treatments for chronic hepatitis B are needed. Lamivudine, the (-)enantiomer of 3'-thiacytidine, is a potent inhibitor of hepatitis B virus (HBV). METHODS: In a double-blind trial, we randomly assigned 32 patients with chronic hepatitis B (including 17 who had no response to earli...

Subject

Medicine

Lamivudine

Virology

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