Cross Kingdom Functional Conservation of the Core Universally Conserved Threonylcarbamoyladenosine tRNA Synthesis Enzymes

C. Thiaville, Patrick; El Yacoubi, Basma; Perrochia, Ludovic; Hecker, Arnaud; Prigent, Magali; J. Thiaville, Jennifer; Forterre, Patrick; Namy, Olivier; Basta, Tamara; de Crécy‐Lagard, Valérie

doi:10.1128/ec.00147-14

Public

Cross Kingdom Functional Conservation of the Core Universally Conserved Threonylcarbamoyladenosine tRNA Synthesis Enzymes

Published in Eukaryotic Cell • Jul 19, 2014

Authors:

Patrick C. Thiaville

Basma El Yacoubi

Ludovic Perrochia

Abstract

Threonylcarbamoyladenosine (t(6)A) is a universal modification located in the anticodon stem-loop of tRNAs. In yeast, both cytoplasmic and mitochondrial tRNAs are modified. The cytoplasmic t(6)A synthesis pathway was elucidated and requires Sua5p, Kae1p, and four other KEOPS complex proteins. Recent...

Subject

Complementation

Transfer RNA

Cytoplasm

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