Affinity of Two Novel Five-Coordinated Anticancer Pt(II) Complexes to Human and Bovine Serum Albumins: A Spectroscopic Approach

Samari, Fayezeh; Hemmateenejad, Bahram; Shamsipur, Mojtaba; Rashidi, Mehdi; Samouei, Hamidreza

doi:10.1021/ic202141g

Public

Affinity of Two Novel Five-Coordinated Anticancer Pt(II) Complexes to Human and Bovine Serum Albumins: A Spectroscopic Approach

Published in Inorganic Chemistry • Feb 24, 2012

Authors:

Fayezeh Samari

Bahram Hemmateenejad

Mojtaba Shamsipur

Abstract

The interactions of two organoplatinum complexes, [Pt(C^N)Cl(dppa)], 1, and [Pt(C^N)Cl(dppm)], 2 (C^N = N(1), C(2')-chelated, deprotonated 2-phenylpyridine, dppa = bis(diphenylphosphino)amine, dppm = bis(diphenylphosphino)methane), as antitumor agents, with bovine serum albumin (BSA) and human serum...

Subject

Chemistry

Bovine serum albumin

Binding constant

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