Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B

McKenzie, Robin; Fried, Michael; Sallie, Richard; S. Conjeevaram, Hari; M. Di Bisceglie, Adrian; Park, Yoon; Savarese, Barbara; E. Kleiner, David; Tsokos, Maria; A. Luciano, Carlos; L. Pruett, Timothy; L. Stotka, Jennifer; E. Straus, Stephen; H. Hoofnagle, Jay

doi:10.1056/nejm199510263331702

Public

Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B

Published in New England Journal of Medicine • Oct 26, 1995

Authors:

Robin McKenzie

Michael Fried

Richard Sallie

Abstract

BACKGROUND: We describe severe and unexpected multisystem toxicity that occurred during a study of the antiviral nucleoside analogue fialuridine (1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil, or FIAU) as therapy for chronic hepatitis B virus infection. METHODS: Fifteen patients with chr...

Subject

Medicine

Lactic acidosis

Gastroenterology

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