Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya.

Sanada, M; Miyano, Tetsuji; Iwadare, Shuichi; M. Williamson, Joanne; H. Arison, Byron; L. Smith, Jack; W. Douglas, Alan; M. Liesch, Jerrold; Inamine, Edward

doi:10.7164/antibiotics.39.259

Public

Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya.

Published in The Journal of Antibiotics • Jan 1, 1986

Authors:

M Sanada

Tetsuji Miyano

Shuichi Iwadare

Abstract

An antimetabolite, THX, was isolated from fermentation broths of the thienamycin producer, Streptomyces cattleya, when the organism was grown in the presence of a fluorine-containing substrate. THX was subsequently identified as one of the four possible stereoisomers of 4-fluorothreonine. Inorganic ...

Subject

Thienamycin

Fermentation

Fluoroacetate

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