Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

Papa, Linda; M. Brophy, Gretchen; D. Welch, Robert; M. Lewis, Lawrence; F. Braga, Carolina; N. Tan, Ciara; J. Ameli, Neema; Antonio López, Marco; A. Haeussler, Crystal; I. Mendez Giordano, Diego; Silvestri, Salvatore; Giordano, Philip; Weber, Kurt; Hill-Pryor, Crystal; C. Hack, Dallas

doi:10.1001/jamaneurol.2016.0039

Public

Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

Published in JAMA Neurology • Mar 28, 2016

Authors:

Linda Papa

Gretchen M. Brophy

Robert D. Welch

Abstract

IMPORTANCE: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been widely studied and show promise for clinical usefulness in suspected traumatic brain injury (TBI) and concussion. Understanding their diagnostic accuracy over time will help translate them int...

Subject

Traumatic brain injury

Cohort

Medicine

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