The Risk of Cancer Associated with Specific Mutations of<i>BRCA1</i>and<i>BRCA2</i>among Ashkenazi Jews

P. Struewing, Jeffery; Hartge, Patricia; Wacholder, Sholom; M. Baker, Sonya; Berlin, Martha; McAdams, Mary; M. Timmerman, Michelle; C. Brody, Lawrence; A. Tucker, Margaret

doi:10.1056/nejm199705153362001

Public

The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews

Published in New England Journal of Medicine • May 15, 1997

Authors:

Jeffery P. Struewing

Patricia Hartge

Sholom Wacholder

Abstract

BACKGROUND: Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have an 85 percent risk of breast cancer. Since the combined frequency of BRCA1 and BRCA2 mutations exceeds 2 percent among Ashkenazi Jews, we were able to estimate the risk of...

Subject

Medicine

Breast cancer

Ovarian cancer

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