Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

W. Moreland, Larry; W. Baumgartner, Scott; Schiff, Michael; A. Tindall, Elizabeth; Fleischmann, Roy; L. Weaver, Arthur; E. Ettlinger, Robert; Cohen, Stanley; J. Koopman, William; M. Mohler, Kendall; B. Widmer, Michael; Blosch, Consuelo

doi:10.1056/nejm199707173370301

Public

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

Published in New England Journal of Medicine • Jul 17, 1997

Authors:

Larry W. Moreland

Scott W. Baumgartner

Michael Schiff

Abstract

BACKGROUND: Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis, and antagonism of TNF may reduce the activity of the disease. This study evaluated the safety and efficacy of a novel TNF antagonist - a recombinant fusion protein that consist...

Subject

Medicine

Rheumatoid arthritis

Placebo

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