Inactivation of the DNA-Repair Gene<i>MGMT</i>and the Clinical Response of Gliomas to Alkylating Agents

Esteller, Manel; García‐Foncillas, Jesús; Andion, Esther; N. Goodman, Steven; Fernández Hidalgo, O.; Vanaclocha, Vicente; B. Baylin, Stephen; G. Herman, James

doi:10.1056/nejm200011093431901

Public

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

Published in New England Journal of Medicine • Nov 9, 2000

Authors:

Manel Esteller

Jesús García‐Foncillas

Esther Andion

Abstract

BACKGROUND: The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a promoter; methylation of the promoter silences the gene in cancer, and the cells no longer produce MGMT. We examined gliomas to d...

Subject

Carmustine

Methyltransferase

Methylation

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