Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

M, Esteller; J, Garcia-Foncillas; E, Andion; SN, Goodman; OF, Hidalgo; V, Vanaclocha; SB, Baylin; JG, Herman

doi:10.1056/nejm200011093431901

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

Shared by NobleBlocks on Nov 1, 2000 • 12:00 AM UTC

Authors:

Esteller M

Garcia-Foncillas J

Andion E

Abstract

Background The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a promoter; methylation of the promoter silences the gene in cancer, and the cells no longer produce MGMT. We examined gliomas to de...

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