Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

Farber, Sidney; K. Diamond, Louis; D. Mercer, Robert; F. Sylvester, Robert; A. Wolff, James

doi:10.1056/nejm194806032382301

Public

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

Published in New England Journal of Medicine • Jun 3, 1948

Authors:

Sidney Farber

Louis K. Diamond

Robert D. Mercer

Abstract

IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia treated by the intramuscular injection of a synthetic compound, 4-aminopteroylglutamic acid (aminopterin). This substance is an antagonist to folic acid regarding the growth of...

Subject

Aminopterin

Folic Acid Antagonists

Medicine

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