Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.

Chen, Baoen; Ye, Fei; Yu, Lu; Jia, Guifang; Huang, Xiaotian; Zhang, Xueju; Peng, Shuying; Chen, Kai; Wang, Meining; Gong, Shouze; Zhang, Ruihan; Yin, Jinya; Li, Haiyan; Yang, Yiming; Liu, Hong; Zhang, Jiwen; Zhang, Haiyan; Zhang, Ao; Jiang, Hualiang; Luo, Cheng; Yang, Cai-Guang

doi:10.1021/ja3064149

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Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.

Shared by NobleBlocks on Oct 31, 2012 • 12:00 AM UTC

Authors:

Baoen Chen

Fei Ye

Lu Yu

Abstract

The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with structure-based virtual screening ...

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