FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

Kino, Toru; Hatanaka, Hiroshi; Miyata, Susumu; Inamura, Noriaki; Nishiyama, Michihisa; YAJIMA, TOSHIMI; Goto, Toshio; OKUHARA, MASAKUNI; KOHSAKA, MASANOBU; AOKI, HATSUO; Ochiai, Takenori

doi:10.7164/antibiotics.40.1256

Public

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

Published in The Journal of Antibiotics • Jan 1, 1987

Authors:

Toru Kino

Hiroshi Hatanaka

Susumu Miyata

Abstract

The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T ce...

Subject

In vitro

Immune system

Interleukin 2

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