Independent Emergence of the Plasmodium falciparum Kelch Propeller Domain Mutant Allele C580Y in Guyana.

SM, Chenet; Okoth S, Akinyi; CS, Huber; J, Chandrabose; NW, Lucchi; E, Talundzic; K, Krishnalall; N, Ceron; L, Musset; de Oliveira A, Macedo; M, Venkatesan; R, Rahman; JW, Barnwell; V, Udhayakumar

doi:10.1093/infdis/jiv752

Public

Independent Emergence of the Plasmodium falciparum Kelch Propeller Domain Mutant Allele C580Y in Guyana.

Shared by NobleBlocks on Dec 21, 2015 • 12:00 AM UTC

Authors:

Chenet SM

Akinyi Okoth S

Huber CS

Abstract

Suspected artemisinin resistance in Plasmodium falciparum can be explored by examining polymorphisms in the Kelch (PfK13) propeller domain. Sequencing of PfK13 and other gene resistance markers was performed on 98 samples from Guyana. Five of these samples carried the C580Y allele in the PfK13 prope...

Subject

Malaria

Plasmodium falciparum

South America

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