Independent Emergence of thePlasmodium falciparumKelch Propeller Domain Mutant Allele C580Y in Guyana

M. Chenet, Stella; Okoth, Sheila; S. Huber, Curtis; Chandrabose, Javin; W. Lucchi, Naomi; Talundzic, Eldin; Krishnalall, Karanchand; Ceron, Nicolas; Musset, L.; Macedo de Oliveira, Alexandre; Venkatesan, Meera; Rahman, Reyaud; W. Barnwell, John; Udhayakumar, Venkatachalam

doi:10.1093/infdis/jiv752

Public

Independent Emergence of thePlasmodium falciparumKelch Propeller Domain Mutant Allele C580Y in Guyana

Published in The Journal of Infectious Diseases • Dec 21, 2015

Authors:

Stella M. Chenet

Sheila Okoth

Curtis S. Huber

Abstract

Suspected artemisinin resistance in Plasmodium falciparum can be explored by examining polymorphisms in the Kelch (PfK13) propeller domain. Sequencing of PfK13 and other gene resistance markers was performed on 98 samples from Guyana. Five of these samples carried the C580Y allele in the PfK13 prope...

Subject

Allele

Plasmodium falciparum

Artemisinin

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