Safety and efficacy of outpatient treatment with CPT-11 plus bolus folinic acid/5-fluorouracil as first-line chemotherapy for metastatic colorectal cancer

Moehler, Markus; Hoffmann, Tanja; Zanke, C.; Hohl, Horst; Burg, Helmut; Ehscheid, Peter; Schwindt, P; Adami, Bernd; Schroeder, Martin; Klein, O.; Baldus, M.; R. Galle, Peter; Heike, Michael

doi:10.1097/00001813-200301000-00011

Public

Safety and efficacy of outpatient treatment with CPT-11 plus bolus folinic acid/5-fluorouracil as first-line chemotherapy for metastatic colorectal cancer

Published in Anti-Cancer Drugs • Jan 1, 2003

Authors:

Markus Moehler

Tanja Hoffmann

C. Zanke

Abstract

The combination of irinotecan (CPT-11), bolus 5-fluorouracil (5-FU) and folinic acid (FA) (Saltz regimen) has recently been questioned as first-line chemotherapy for metastatic colorectal cancer after high early death rates due to gastrointestinal and thromboembolic events were reported in two US tr...

Subject

Medicine

Folinic acid

Irinotecan

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