Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

Giaid, Adel; Yanagisawa, Masashi; Langleben, David; P. Michel, René; D. Levy, Robert; Shennib, Hani; Kimura, Sadao; Masaki, Τοmoh; P. Duguid, William; J. Stewart, Duncan

doi:10.1056/nejm199306173282402

Public

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

Published in New England Journal of Medicine • Jun 17, 1993

Authors:

Adel Giaid

Masashi Yanagisawa

David Langleben

Abstract

BACKGROUND: Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells in the walls of small pulmonary arteries. Endothelin-1 is a potent endothelium-derived vasoconstrictor peptide with important mitogenic properties. It has therefore been s...

Subject

Pulmonary hypertension

Medicine

Endothelin 1

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