Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease

Vichinsky, Elliott; Neumayr, Lynne; N. Earles, Ann; Williams, Roger; T. Lennette, Evelyne; Dean, Deborah; G. Nickerson, Bruce; P. Orringer, Eugene; McKie, Virgil; Bellevue, Rita; Daeschner, Charles; R. Abboud, Miguel; D. Moncino, Mark; K. Ballas, Samir; E. Ware, Russell; A. Manci, Elizabeth

doi:10.1056/nejm200006223422502

Public

Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease

Published in New England Journal of Medicine • Jun 22, 2000

Authors:

Elliott Vichinsky

Lynne Neumayr

Ann N. Earles

Abstract

BACKGROUND: The acute chest syndrome is the leading cause of death among patients with sickle cell disease. Since its cause is largely unknown, therapy is supportive. Pilot studies with improved diagnostic techniques suggest that infection and fat embolism are underdiagnosed in patients with the syn...

Subject

Medicine

Acute chest syndrome

Pneumonia

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