Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis

J. Fuchs, Henry; Borowitz, Drucy; Høyrup Christiansen, David; M. Morris, Edward; L. Nash, Martha; W. Ramsey, Bonnie; J. Rosenstein, Beryl; L. Smith, Arnold; Ellen B. Wohl, Mary

doi:10.1056/nejm199409083311003

Public

Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis

Published in New England Journal of Medicine • Sep 8, 1994

Authors:

Henry J. Fuchs

Drucy Borowitz

David Høyrup Christiansen

Abstract

BACKGROUND: Respiratory disease in patients with cystic fibrosis is characterized by airway obstruction caused by the accumulation of thick, purulent secretions, which results in recurrent, symptomatic exacerbations. The viscoelasticity of the secretions can be reduced in vitro by recombinant human ...

Subject

Cystic fibrosis

Medicine

Recombinant DNA

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