Influence of the Genotype on the Clinical Course of the Long-QT Syndrome

Zaręba, Wojciech; J. Moss, Arthur; J. Schwartz, Peter; Michael Vincent, G.; L. Robinson, Jennifer; G. Priori, Silvia; Benhorin, Jesaia; H. Locati, Emanuela; A. Towbin, Jeffrey; T. Keating, Mark; H. Lehmann, Michael; J. Hall, William; Andrews, Mark; Napolitano, Carlo; W. Timothy, Katherine; Zhang, Li; Medina, Aharon; W. MacCluer, Jean

doi:10.1056/nejm199810013391404

Public

Influence of the Genotype on the Clinical Course of the Long-QT Syndrome

Published in New England Journal of Medicine • Oct 1, 1998

Authors:

Wojciech Zaręba

Arthur J. Moss

Peter J. Schwartz

Abstract

BACKGROUND: The congenital long-QT syndrome, caused by mutations in cardiac potassium-channel genes (KVLQT1 at the LQT1 locus and HERG at the LQT2 locus) and the sodium-channel gene (SCN5A at the LQT3 locus), has distinct repolarization patterns on electrocardiography, but it is not known whether th...

Subject

Locus (genetics)

Long QT syndrome

Genotype

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