Sensitive Electrochemical Detection of Telomerase Activity Using Spherical Nucleic Acids Gold Nanoparticles Triggered Mimic-Hybridization Chain Reaction Enzyme-Free Dual Signal Amplification

Wang, Wenjing; Li, Jingjing; Rui, Kai; Gai, Panpan; Zhang, Jianrong; Zhu, Jun‐Jie

doi:10.1021/ac504652e

Public

Sensitive Electrochemical Detection of Telomerase Activity Using Spherical Nucleic Acids Gold Nanoparticles Triggered Mimic-Hybridization Chain Reaction Enzyme-Free Dual Signal Amplification

Published in Analytical Chemistry • Feb 11, 2015

Authors:

Wenjing Wang

Jingjing Li

Kai Rui

Abstract

We report an electrochemical sensor for telomerase activity detection based on spherical nucleic acids gold nanoparticles (SNAs AuNPs) triggered mimic-hybridization chain reaction (mimic-HCR) enzyme-free dual signal amplification. In the detection strategy, SNAs AuNPs and two hairpin probes were emp...

Subject

Chemistry

Colloidal gold

Nucleic acid

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