Comprehensive molecular characterization of clear cell renal cell carcinoma

J. Creighton, Chad; Morgan, Margaret; H. Gunaratne, Preethi; A. Wheeler, David; A. Gibbs, Richard; Dm, Muzny; Davis, Caleb; Liu, X; Chang, Kyle; Kakkar, Nipun; R. Treviño, Lisa; Benton, Susan; G. Reid, Jeffrey; Morton, Donna; Doddapaneni, Harsha; Han, Yi; Lewis, Lora; Dinh, Huyen; Kovar, Christie; Zhu, Yiming; Santibanez, Jireh; Wang, Min; Hale, Walker; Kalra, Divya; Xiao, Weimin; Gordon Robertson, A.; Chu, Andy; E. Chun, Hye-Jung; J. Mungall, Andrew; Sipahimalani, Payal; Stoll, Dominik; Ai, Ally; Balasundaram, Miruna; S.N. Butterfield, Yaron; Carlsen, Rebecca; Carter, Candace; Chuah, Eric; Coope, Robin; Dhalla, Noreen; Sl, Gorski; Guin, Ranabir; F Hirst, C; Hirst, Martin; A. Holt, Robert; Lebovitz, Chandra; Lee, Darlene; I. Li, Haiyan; Mayo, Michael; A. Moore, Richard; Pleasance, Erin; Plettner, Patrick; E. Schein, Jacqueline; Shafiei, Arash; R. Slobodan, Jared; Tam, Angela; Thiessen, Nina; Varhol, Richard; Wye, Natasja; Zhao, Yongjun; Birol, İnanç; J.M. Jones, Steven; A. Marra, Marco; Beroukhim, Rameen; Cibulskis, Kristian; Gs, Getz; S. Lawrence, Michael; Sougnez, Carrie; L. Carter, Scott; Sivachenko, Andrey; Lichtenstein, Lee; Stewart, Chip; Voet, Doug; Fisher, Sheila; B. Gabriel, Stacey; Lander, Eric; E. Schumacher, Steve; Tabak, Barbara; Saksena, Gordon; C. Onofrio, Robert; D. Cherniack, Andrew; Gentry, Jeff; Ardlie, Kristin; Meyerson, M.; S. Noble, Michael; DiCara, Daniel; Zhang, Hailei; Cho, Juok; I. Heiman, David; Gehlenborg, Nils; Mallard, William; Lin, Pei; Frazer, Scott; Stojanov, P.; Liu, Yingchun; Lihua, Zhou; Kim, Jaegil; Chin, Lynda; Signoretti, Sabina; Vandin Hsin-Ta Wu, Fabio; J. Raphael, Benjamin; Vandin, Fabio; Wu, Hsin-Ta; G. W. Verhaak, Roel; Torres‐García, Wandaliz; Akbani, Rehan; N. Weinstein, John; G. W. Verhaak, Roel; Vegesna, Rahul; Kim, Hoon; Jonasch, Eric; Ding, Zhiyong; Zhang, Nianxiang; K. Unruh, Anna; D. Casasent, Tod; Wakefield, Chris; Tamboli, Pheroze; Zhang, Wei; Cogdell, David; Czerniak, B; D. Aldape, Kenneth; Ve, Reuter; Rose Brannon, A.; F. Berger, Michael; Tickoo, Satish; J. Hsieh, James; Ari Hakimi, A.; Ladanyi, Marc; Jacobsen, Anders; Ciriello, Giovanni; Reva, Boris; Schultz, Nikolaus; Antipin, Yevgeniy; Gao, Jianjiong; Cerami, Ethan; Gross, Benjamin; Aksoy, B; Sinha, Rileen; Weinhold, Nils; Onur Sumer, S.; S. Taylor, Barry; Shen, Ronglai; Sander, Chris; J. Ricketts, Christopher; Marston Linehan, W.; D. Vocke, Cathy; Peterson, James; Rv, Worrell; Merino, Maria; S. Schmidt, Laura; M. Stuart, Joshua; Ng, Sam; Paull, Evan; B. Carlin, D.; Goldstein, Theodore; Waltman, Peter; Ellrott, Kyle; Zhu, Jing; Haussler, David; Kimryn Rathmell, W.; A. Hoadley, Katherine; Liquori, Christina; J. Turman, Yidi; Shi, Yan; Waring, Scot; Buda, Elizabeth; Walsh, Jesse; Wu, Junyuan; Bodenheimer, Tom; P. Hoyle, Alan; V. Simons, Janae; G. Soloway, Mathew; Balu, Saianand; S. Parker, Joel; Neil Hayes, D; M. Perou, Charles; Thorne, Leigh; Boice, Lori; Huang, Mei; C. Fisher, Jennifer; Shen, Hui; O Laird, P; Triche, Timothy; J. Weisenberger, Daniel; H. Lai, Phillip; Bootwalla, Moiz; T. Maglinte, Dennis; Mahurkar, Swapna; P. Berman, Benjamin; J. Van Den Berg, David; Jt, Auman; Tan, Donghui; D. Jones, Corbin; E. Mose, Lisle; D. Topal, Michael; A. Mieczkowski, Piotr; R. Jefferys, Stuart; Kucherlapati, Raju; H Park, P; Cope, Leslie; Sb, Baylin; M. Reynolds, Sheila; Shmulevich, Ilya; Lu, Yiling; Tsavachidou, Dimitra; B Mills, G; Ostrovnaya, Irina; S. Fei, Suzanne; Stout, Andrew; T. Spellman, Paul; L. Rubin, Daniel; Liu, Tiffany; Shelton, Candace; Gardner, Johanna; Penny, Robert; Sherman, Mark; Mallery, David; Morris, Scott; Paulauskis, Joseph; Burnett, Ken; Shelton, Troy; Curley, Erin; B. Atkins, Michael; G. Wood, Christopher; Boyd, Jeff; Weaver, JoEllen; Iacocca, Mary; Petrelli, Nicholas; Witkin, Gary; Brown, Jennifer; Czerwinski, Christine; Huelsenbeck-Dill, Lori; Rabeno, Brenda; Myers, Jerome; Morrison, Carl; Bergsten, Julie; Eckman, John; R Harr, J; Smith, Christine; Tucker, Kelinda; Anne Zach, Leigh; Bshara, Wiam; Gaudioso, Carmelo; Dhir, Rajiv; Maranchie, Jodi; Nelson, Joel; Parwani, Anil; Potapova, Olga; Kv, Fedosenko; M. Mosquera, Juan; A. Rubin, M.; L. Blute, Michael; Pihl, T; A. Jensen, Mark; Sfeir, Robert; Kahn, Ari; Chu, Anna; Kothiyal, Prachi; Snyder, Eric; Pontius, Joan; Ayala, Brenda; Backus, Mark; Walton, Jessica; Baboud, Julien; Berton, Dominique; Nicholls, Matthew; Dp, Srinivasan; Raman, Rohini; Girshik, Stanley; A. Kigonya, Peter; Alonso, Shelley; N. Sanbhadti, Rashmi; P. Barletta, Sean; Dj, Pot; Sheth, Margi; A. Demchok, John; Davidsen, Tanja; Wang, Zhining; Yang, Liming; W. Tarnuzzer, Roy; Zhang, Jiashan; R. Mills Shaw, Kenna; Eley, Greg; L. Ferguson, Martin; S. Guyer, Mark; A. Ozenberger, Bradley; J. Sofia., Heidi; G. Kaelin, William; Choueiri, Toni; Benz, Christopher; Yau, C; C. Cheville, John; Houston Thompson, R.

doi:10.1038/nature12222

Public

Comprehensive molecular characterization of clear cell renal cell carcinoma

Published in Nature • Jun 23, 2013

Authors:

Chad J. Creighton

Margaret Morgan

Preethi H. Gunaratne

Abstract

Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, PBRM1). We surveyed more than 400 tumours using different genomic platforms and identified 19 s...

Subject

Renal cell carcinoma

Characterization (materials science)

Clear cell renal cell carcinoma

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