Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of Laterality

Britz-Cunningham, Scott; M. Shah, Maithili; W. Zuppan, Craig; H. Fletcher, William

doi:10.1056/nejm199505183322002

Public

Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of Laterality

Published in New England Journal of Medicine • May 18, 1995

Authors:

Scott Britz-Cunningham

Maithili M. Shah

Craig W. Zuppan

Abstract

BACKGROUND: Gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell coupling. We hypothesized tha...

Subject

Transfection

Gap junction

Serine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!