The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Steinbach, Gideon; M. Lynch, Patrick; Phillips, Robin; Wallace, Marina; T. Hawk, Ernest; Gordon, Gary; Wakabayashi, Naoki; P. Saunders, Brian; Shen, Yu; Fujimura, Takashi; Su, Li-Kuo; Levin, Bernard; B. GODIO, LOUIS; Patterson, Sherri; A. Rodrı́guez-Bigas, Miguel; L. Jester, Susan; L. King, Karen; Schumacher, Marta; L. Abbruzzese, James; N. DuBois, Raymond; N. Hittelman, Walter; O. Zimmerman, Stuart; W. Sherman, Jeffrey; J. Kelloff, Gary

doi:10.1056/nejm200006293422603

Public

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Published in New England Journal of Medicine • Jun 29, 2000

Authors:

Gideon Steinbach

Patrick M. Lynch

Robin Phillips

Abstract

BACKGROUND: Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2. METHODS: We studied the effect of celecoxib, a sel...

Subject

Medicine

Familial adenomatous polyposis

Celecoxib

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