Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

K. Mackay, Laura; Minnich, Martina; A. M. Kragten, Natasja; Liao, Yang; Nota, Benjamin; Seillet, Cyril; Zaid, Ali; Man, Kevin; Preston, Simon; Freestone, David; Braun, Asolina; Wynne-Jones, Erica; M. Behr, Felix; Stark, Regina; G. Pellicci, Daniel; I. Godfrey, Dale; T. Belz, Gabrielle; Pellegrini, Marc; Gebhardt, Thomas; Busslinger, Meinrad; Shi, Wei; R. Carbone, Francis; A. W. van Lier, René; Kallies, Axel; P. J. M. van Gisbergen, Klaas

doi:10.1126/science.aad2035

Public

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Published in Science • Apr 21, 2016

Authors:

Laura K. Mackay

Martina Minnich

Natasja A. M. Kragten

Abstract

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptio...

Subject

Biology

Medical education

Computer science

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