Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

K, Clément; C, Vaisse; BS, Manning; A, Basdevant; B, Guy-Grand; J, Ruiz; KD, Silver; AR, Shuldiner; P, Froguel; AD, Strosberg

doi:10.1056/nejm199508103330605

Public

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

Shared by NobleBlocks on Aug 1, 1995 • 12:00 AM UTC

Authors:

Clément K

Vaisse C

Manning BS

Abstract

Background The beta 3-adrenergic receptor, located mainly in adipose tissue, is involved in the regulation of lipolysis and thermogenesis. The potential relevance of this receptor to obesity in humans led us to screen obese French patients for a recently identified mutation in the gene for the recep...

Discussions