Genetic Variation in the β3-Adrenergic Receptor and an Increased Capacity to Gain Weight in Patients with Morbid Obesity

Clément, Karine; Vaisse, Christian; S. Manning, Brian; Basdevant, Arnaud; Guy-Grand, B; Carlos Ruiz, Juan; D. Silver, Kristi; R. Shuldiner, Alan; Froguel, Philippe; Donny Strosberg, A.

doi:10.1056/nejm199508103330605

Public

Genetic Variation in the β3-Adrenergic Receptor and an Increased Capacity to Gain Weight in Patients with Morbid Obesity

Published in New England Journal of Medicine • Aug 10, 1995

Authors:

Karine Clément

Christian Vaisse

Brian S. Manning

Abstract

BACKGROUND: The beta 3-adrenergic receptor, located mainly in adipose tissue, is involved in the regulation of lipolysis and thermogenesis. The potential relevance of this receptor to obesity in humans led us to screen obese French patients for a recently identified mutation in the gene for the rece...

Subject

Medicine

Lipolysis

Thermogenesis

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