Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

J. Gandal, Michael; R. Haney, Jillian; Parikshak, Neelroop; Leppä, Virpi; Ramaswami, Gokul; Hartl, Christopher; J. Schork, Andrew; Appadurai, Vivek; Buil, Alfonso; Werge, Thomas; Liu, Chunyu; P. White, Kevin; Working Group, iPSYCH-BROAD; Horvath, Steve; H. Geschwind, Daniel; Šestan, Nenad; M. Vaccarino, Flora; Gerstein, Mark; M. Weissman, Sherman; Pochareddy, Sirisha; W. State, Matthew; A. Knowles, James; Farnham, Peggy; Akbarian, Schahram; Pinto, Dalila; Van Baekl, Harm; Dracheva, Stella; E. Jaffe, Andrew; M. Hyde, Thomas; P. Zandi, Peter; E. Crawford, Gregory; Sullivan, Pat; K. Thompson, Wesley; Bo Mortensen, Preben; Agerbo, Esben; Giørtz Pedersen, Marianne; Bøcker Pedersen, Carsten; Mors, Ole; D. Børglum, Anders; Nordentoft, Merete; M. Hougaard, David; Bybjerg‐Grauholm, Jonas; Bækvad‐Hansen, Marie; R. Martin, Alicia; Dumont, Ashley; Stevens, Christine; Churchhouse, Claire; P. Howrigan, Daniel; S. Palmer, Duncan; Robinson, Elise; Satterstrom, Kyle; Cerrato, Felecia; Huang, Hailiang; I. Goldstein, Jacqueline; L. Moran, Jennifer; Martin Julian, Joanna; Alonge Kimberly, M.; Seed Patrick, C.; Turley, Patrick; K. Walters, Raymond; Belliveau, Rich; Ripke, Stephan; Poterba, Timothy; J. Daly, Mark; M. Neale, Benjamin; Fromer, Menachem; Roussos, Panos; Johnson, Jessica; Shah, Hardik; Mahajan, Milind; E. Schadt, Eric; Haroutunian, Vahram; M. Ruderfer, Douglas; D. Buxbaum, Joseph; K. Sieberts, Solveig; K. Dang, Kristen; Logsdon, Ben; M. Mangravite, Lara; A. Peters, Mette; E. Gur, Raquel; Hahn, Chang-Gyu; Devlin, Bernie; Klei, Lambertus; A. Lewis, David; K. Lipska, Barbara; Hirai, Keisuke; Toyoshiba, Hiroyoshi; Domenici, Enrico

doi:10.1126/science.aad6469

Public

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Published in Science • Feb 9, 2018

Authors:

Michael J. Gandal

Jillian R. Haney

Neelroop Parikshak

Abstract

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotype...

Subject

Neuropathology

Parallels

Psychiatry

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