Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Healthy Children and Adults in Dengue-Endemic Regions: A Randomized, Placebo-Controlled Phase 2 Study

Sirivichayakul, Chukiat; A Barranco-Santana, Elizabeth; Esquilin-Rivera, Inés; Oh, Helen; G. Raanan, Marsha; A. Sariol, Carlos; Pei‐Chi Shek, Lynette; Simasathien, Sriluck; Kathryn Smith, Mary; Darío Vélez, Iván; Wallace, Derek; S. Gordon, Gilad; T. Stinchcomb, Dan

doi:10.1093/infdis/jiv762

Public

Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Healthy Children and Adults in Dengue-Endemic Regions: A Randomized, Placebo-Controlled Phase 2 Study

Published in The Journal of Infectious Diseases • Dec 23, 2015

Authors:

Chukiat Sirivichayakul

Elizabeth A Barranco-Santana

Inés Esquilin-Rivera

Abstract

BACKGROUND: A safe, effective tetravalent dengue vaccine is a global health priority. The safety and immunogenicity of a live attenuated, recombinant tetravalent dengue vaccine candidate (TDV) were evaluated in healthy volunteers from dengue-endemic countries. METHODS: This multicenter, double-blind...

Subject

Dengue fever

Dengue vaccine

Immunogenicity

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