A Vaccine Consisting of Recombinant<i>Borrelia burgdorferi</i>Outer-Surface Protein A to Prevent Lyme Disease

H. Sigal, Leonard; M. Zahradnik, John; T. Lavin, Philip; J. Patella, Sondra; Bryant, Gary; Haselby, Ray; Hilton, Eileen; Künkel, M; Adler-Klein, D.; J. Doherty, Terrence; Evans, Janine; E. Malawista, Stephen; J. Molloy, Philip; Seidner, A.; R. Sabetta, James; J. Simon, H.; S. Klempner, Mark; Mays, John; H. Marks, Donald

doi:10.1056/nejm199807233390402

Public

A Vaccine Consisting of RecombinantBorrelia burgdorferiOuter-Surface Protein A to Prevent Lyme Disease

Published in New England Journal of Medicine • Jul 23, 1998

Authors:

Leonard H. Sigal

John M. Zahradnik

Philip T. Lavin

Abstract

BACKGROUND: Lyme disease is a multisystem inflammatory disease caused by infection with the tick-borne spirochete Borrelia burgdorferi and is the most common vector-borne infection in the United States. We assessed the efficacy of a recombinant vaccine consisting of outer-surface protein A (OspA) wi...

Subject

Lyme disease

Medicine

Borrelia burgdorferi

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