Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

K. Speliotes, Elizabeth; J. Willer, Cristen; I. Berndt, S.; L. Monda, Keri; Þorleifsson, Guðmar; Jackson, Anvesh; Lango Allen, Hana; M. Lindgren, Cecilia; Luan, Jian; Mägi, Reedik; C. Randall, Joshua; Vedantam, Sailaja; W. Winkler, Thomas; Qi, Lu; Workalemahu, Tsegaselassie; M. Heid, Iris; Steinthórsdóttir, Valgerður; M. Stringham, Heather; N. Weedon, Michael; Wheeler, Eleanor; Wood, Abigail; Ferreira, Teresa; J. Weyant, Robert; V. Segrè, Ayellet; Estrada, Karol; Liang, Liming; Nemesh, James; H. Park, J.; Gustafsson, Stefan; O. Kilpeläinen, Tuomas; Yang, Jiwon; Bouatia‐Naji, Nabila; Esko, Tõnu; Feitosa, M.F.; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, André; V. Smith, Albert; Welch, Robert; Hua Zhao, Jing; K.H. Aben, Katja; Absher, Devin; Amin, Najaf; Dixon, Ajeya; Fisher, Elizabeth; L. Glazer, Nicole; E. Goddard, Michael; L. Heard‐Costa, Nancy; Hoesel, Volker; Hottenga, J-J; Johansson, Åsa; Johnson, Thomas; Ketkar, Shamika; Lamina, Claudia; Li, S.; F. Moffatt, Miriam; H. Myers, Richard; Narisu, N; R. B. Perry, John; J. Peters, Marjolein; Preuß, Michael; Ripatti, Samuli; Rivadeneira, Fernando; H. Sandholt, Camilla; J. Scott, Laura; J. Timpson, Nicholas; P. Tyrer, J.; van Wingerden, S.; M. Watanabe, Richard; C. White, Charles; Wiklund, Fredrik; Barlassina, Cristina; I. Chasman, Daniel; N. Cooper, Matthew; Jansson, Jan-Hakan; Lawrence, Robert; Pellikka, Niina; Prokopenko, Inga; Shi, Juanzi; Thiering, Elisabeth; Alavere, Helen; Teresa Sciarrone Alibrandi, Maria; Almgren, Peter; M. Arnold, Alice; Aspelund, Thor; D. Atwood, Larry; Balkau, Beverley; J. Balmforth, Anthony; J. Bennett, Amanda; Ben‐Shlomo, Yoav; N. Bergman, Richard; Bergmann, Sven; Biebermann, Heike; I. F. Blakemore, Alexandra; Boes, Tanja; L. Bonnycastle, Lori; R. Bornstein, Stefan; J. Brown, M.; A. Buchanan, Thomas; Busonero, Fabio; Campbell, Harry; P. Cappuccio, Francesco; Cavalcanti-Proença, Christine; D. Chen, Y.; M. Chen, C.; S. Chines, Peter; A. Clarke, Raymond; Coin, Lachlan; Connell, Jmc; Day, Inm; den Heijer, Martin; Duan, Jiayu; Ebrahim, Shah; Elliott, Paul; Elosúa, Roberto; Eiríksdóttir, G.; R. Erdos, Michael; G. Eriksson, Johan; Facheris, Maurizio; B. Felix, Stephan; Fischer‐Posovszky, Pamela; R. Folsom, Aaron; Friedrich, Nele; B. Freimer, Nelson; Fu, Minjie; Gaget, Stefan; Gejman, PV; J. C. de Geus, Eco; Gieger, Christian; P. Gjesing, Anette; Goel, Anuj; Goyette, Philippe; Grallert, Harald; Gräßler, J; M. Greenawalt, Danielle; J. Groves, Christopher; Guðnason, Vilmundur; Guiducci, C.; Hartikainen, Anna‐Liisa; Hassanali, Neelam; Hall, Ashley; S. Havulinna, Aki; Hayward, Caroline; C. Heath, Andrew; Hengstenberg, Christian; A. Hicks, Andrew; Hinney, Anke; Hofman, Albert; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Iribarren, Carlos; Isomaa, Bo; B. Jacobs, Kevin; Jarick, Ivonne; Jewell, Erica; P. John, Ulrik; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eero; M. Kaplan, Lee; Kathiresan, Sekar; Kettunen, JA; Kinnunen, Leena; W. Knowles, Joshua; Kolčić, Ivana; R. König, Inke; Koskinen, Seppo; Kovács, Péter; Kuusisto, Johanna; Kraft, Peter; Kvaløy, Kirsti; T. Laitinen, Jarmo; Lantieri, Olivier; Lanzani, Chiara; J. Launer, Lenore; Lecoeur, Constant; Lehtimäki, Terho; Lettre, Guillaume; Liu, J.; Lokki, Marja‐Liisa; Lorentzon, Mattias; Luben, Robert; Ludwig, Barbara; Manunta, Paolo; Marek, Diana; Marre, Michel; G. Martin, Nicholas; L. McArdle, Wendy; McCarthy, A.; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Midthjell, Kristian; W. Montgomery, Grant; A. Morken, Mario; P. Morris, A.; Mulić, Rosanda; S. Ngwa, Julius; Nelis, Mari; J. Neville, Matt; R. Nyholt, Dale; O’Donnell, Chris; O’Rahilly, Stephen; Ong, KL; A. Oostra, B.; Paré, Guillaume; N. Parker, Alexander; Perola, Markus; Pichler, Irene; H. Pietiläinen, Kirsi; G. P. Platou, Carl; Polašek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; W Rayner, N; Ridderstråle, Martin; Rief, Winfried; Ruokonen, Aimo; R. Robertson, Neil; Rzehak, Peter; Salomaa, Veikko; R. Sanders, Alan; S. Sandhu, Manjinder; Sanna, Serena; Saramies, J.; J. Savolainen, Markku; Scherag, Susann; Schipf, Sabine; Schreiber, Stefanie; Schunkert, Heribert; Silander, Kaisa; Sinisalo, Juha; S. Siscovick, David; Smit, JH; Soranzo, Nicole; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; J. Swift, Amy; L. Tammesoo, M.; Tardif, Jean‐Claude; Teder‐Laving, Maris; M. Teslovich, Tanya; R. Thompson, John; Thomson, Brian; Tönjes, Anke; Tuomilehto, Jaakko; B. J. van Meurs, Joyce; J van Ommen, G; Vatin, Vincent; Viikari, Jorma; Visvikis‐Siest, Sophie; Vitart, Véronique; Ivane Ganz Vogel, Carla; F. Voight, Benjamin; L. Waite, Lindsay; Wallaschofski, Henri; Bragi Walters, G.; Widén, Elisabeth; Wiegand, Susanna; Wild, SH; Willemsen, Gonneke; R. Witte, Daniel; C.M. Witteman, Jacqueline; Xu, Jing; Zhang, Qunyuan; Zgaga, Lina; Ziegler, Andreas; Zitting, Paavo; Beilby, John; Sadaf Farooqi, I.; Hebebrand, Johannes; Huikuri, Heikki; James, Anthony; Kähönen, Mika; F. Levinson, D.; Macciardi, Fabìo; S. Nieminen, Markku; Ohlsson, Claes; J. Palmer, Lyle; M. Ridker, Paul; Stümvoll, Michael; Beckmann, J.; Boeing, Heiner; Boerwinkle, Eric; I. Boomsma, Dorret; J. Caulfield, Mark; J. Chanock, Stephen; S. Collins, Francis; Adrienne Cupples, L.; Davey Smith, George; Erdmann, Jeanette; Froguel, Philippe; Grönberg, Henrik; Gyllensten, Ulf; Hall, Per; van Overeem Hansen, Thomas; B. Harris, Tamara; T. Hattersley, Andrew; B. Hayes, Richard; Heinrich, Joachim; Hu, Feng; Hveem, Kristian; Illig, Thomas; Järvelin, Marjo‐Riitta; Kaprio, Jaakko; Karpe, Fredrik; Khaw, Kay‐Tee; A. Kiemeney, L.; Krude, Heiko; Laakso, M.; A. Lawlor, Debbie; Metspalu, Andres; B. Munroe, Patricia; H. Ouwehand, Willem; Pedersen, Oluf; W.J.H. Penninx, Brenda; Peters, Annette; P. Pramstaller, Peter; Quertermous, Thomas; Reinehr, Thomas; Rissanen, A; Rudan, Igor; J. Samani, N.; E. H. Schwarz, Peter; R. Shuldiner, Alan; D. Spector, T.; Tuomilehto, J.; Uda, Manuela; G. Uitterlinden, André; T. Valle, T.; Wabitsch, Martin; Waeber, Gérard; J. Wareham, Nicholas; Watkins, Hugh; Frank Wilson, J.; F. Wright, Alan; Carola Zillikens, M.; Chatterjee, N.; A. McCarroll, Steven; Purcell, Shaun; E. Schadt, E.; M. Visscher, Peter; L. Assimes, Themistocles; B. Borecki, Ingrid; Deloukas, Panos; S. Fox, Caroline; Groop, Leif; Haritunians, Talin; J. Hunter, David; Kaplan, R.C.; L. Mohlke, Karen; R. O’Connell, Jeffery; Peltonen, Laura‐Maria; Schlessinger, David; P. Strachan, D.; M. van Duijn, Cornelia; Wichmann, H-Erich; M. Frayling, Timothy; Thorsteinsdottir, U.; R. Abecasis, Gonçalo; Barroso, Inês; Boehnke, Michael; Stefánsson, Kāri; E. North, K.; I. McCarthy, Mark; N. Hirschhorn, J.; Ingelsson, Erik; J. F. Loos, Ruth

doi:10.17615/d3bn-7g86

Public

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Published in Carolina Digital Repository (University of North Carolina at Chapel Hill) • Jan 1, 2010

Authors:

Elizabeth K. Speliotes

Cristen J. Willer

S. I. Berndt

Abstract

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of...

Subject

Genetics

Body mass index

Biology

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