Genome‐Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

E. Alarcón‐Riquelme, Marta; T. Ziegler, Julie; E. Molineros, Julio; D. Howard, Timothy; Moreno‐Estrada, Andrés; Sánchez, Elena; C. Ainsworth, Hannah; A. Ortiz-Tello, Patricia; E. Comeau, Mary; Rasmussen, Astrid; A. Kelly, Jennifer; Adler, Adam; M. Acevedo‐Vásquez, Eduardo; M. Cucho‐Venegas, Jorge; García‐De La Torre, Ignacio; H. Cardiel, Mario; C. Miranda, Pedro; J. Catoggio, Luís; A. Maradiaga‐Ceceña, Marco; M. Gaffney, Patrick; J. Vyse, Timothy; A. Criswell, Lindsey; P. Tsao, Betty; L. Sivils, Kathy; Bae, Sang‐Cheol; A. James, Judith; P. Kimberly, Robert; M. Kaufman, Kenneth; B. Harley, John; Antonio Esquivel‐Valerio, Jorge; F. Moctezuma, J.; García, Mercedes; Berbotto, Guillermo; Babini, Alejandra; R. Scherbarth, Hugo; Toloza, Sergio; Baca, Vicente; K. Nath, Swapan; Aguilar Salinas, Carlos; Orozco, Lorena; Tusié‐Luna, Teresa; Zidovetzki, Raphael; A. Pons‐Estel, Bernardo; D. Langefeld, Carl; O. Jacob, Chaim

doi:10.1002/art.39504

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Genome‐Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

Published in Arthritis & Rheumatology • Nov 25, 2015

Authors:

Marta E. Alarcón‐Riquelme

Julie T. Ziegler

Julio E. Molineros

Abstract

OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component. We undertook the present work to perform the first genome-wide association study on individuals from the Americas who are enriched for Native American heritage. METHODS: We analyzed 3,710 i...

Subject

Genome-wide association study

Expression quantitative trait loci

Imputation (statistics)

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