Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

E Alarcón-Riquelme, Marta; T Ziegler, Julie; Molineros, Julio; D Howard, Timothy; Moreno-Estrada, Andrés; Sánchez-Rodríguez, Elena; C Ainsworth, Hannah; Ortiz-Tello, Patricia; E Comeau, Mary; Rasmussen, Astrid; A Kelly, Jennifer; Adler, Adam; M Acevedo-Vázquez, Eduardo; Mariano Cucho-Venegas, Jorge; García-De la Torre, Ignacio; H Cardiel, Mario; Miranda, Pedro; J Catoggio, Luis; Maradiaga-Ceceña, Marco; M Gaffney, Patrick; J Vyse, Timothy; A Criswell, Lindsey; P Tsao, Betty; L Sivils, Kathy; Bae, Sang-Cheol; A James, Judith; P Kimberly, Robert; M Kaufman, Kenneth; B Harley, John; A Esquivel-Valerio, Jorge; F Moctezuma, José; A García, Mercedes; A Berbotto, Guillermo; M Babini, Alejandra; Scherbarth, Hugo; Toloza, Sergio; Baca, Vicente; K Nath, Swapan; Aguilar Salinas, Carlos; Orozco, Lorena; Tusié-Luna, Teresa; Zidovetzki, Raphael; A Pons-Estel, Bernardo; D Langefeld, Carl; O Jacob, Chaim

doi:10.1002/art.39504

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Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

Shared by NobleBlocks on Apr 1, 2016 • 12:00 AM UTC

Authors:

Marta E Alarcón-Riquelme

Julie T Ziegler

Julio Molineros

Abstract

OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component. We undertook the present work to perform the first genome-wide association study on individuals from the Americas who are enriched for Native American heritage. METHODS: We analyzed 3,710 i...

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