A Short-Term Study of the Safety, Pharmacokinetics, and Efficacy of Ritonavir, an Inhibitor of HIV-1 Protease

A. Danner, Sven; Carr, Andrew; M. Leonard, John; M. Lehman, Leah; Gudiol, Francesc; M. Gonzales, J.; Raventos, Antonio; Rubio, Rafael; Bouza, Emilio; Pintado, Vicente; Gil Aguado, Antonio; García de Lomas, Juan; Delgado, Rafaël; C.C. Borleffs, Jan; Hsu, Ann; Valdes, Joaquin; A. Boucher, Charles; A. Cooper, David

doi:10.1056/nejm199512073332303

Public

A Short-Term Study of the Safety, Pharmacokinetics, and Efficacy of Ritonavir, an Inhibitor of HIV-1 Protease

Published in New England Journal of Medicine • Dec 7, 1995

Authors:

Sven A. Danner

Andrew Carr

John M. Leonard

Abstract

BACKGROUND: Reverse-transcriptase inhibitors have only moderate clinical efficacy against the human immunodeficiency virus type 1 (HIV-1). Ritonavir is an inhibitor of HIV-1 protease with potent in vitro anti-HIV properties and good oral bioavailability. METHODS: We evaluated the antiviral activity ...

Subject

Ritonavir

Medicine

Pharmacokinetics

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