The non-canonical functions of p27 <sup>Kip1</sup> in normal and tumor biology

S. Sharma, Savitha; Jackson Pledger, W.

doi:10.1080/15384101.2016.1157238

Public

The non-canonical functions of p27 Kip1 in normal and tumor biology

Published in Cell Cycle • Apr 15, 2016

Authors:

Savitha S. Sharma

W. Jackson Pledger

Abstract

p27(Kip1) was first discovered as a key regulator of cell proliferation. The canonical function of p27(Kip1) is inhibition of cyclin-dependent kinase (CDK) activity. In addition to its initial identification as a CDK inhibitor, p27(Kip1) has also emerged as an intrinsically unstructured, multifuncti...

Subject

Biology

Cyclin-dependent kinase

Cell biology

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