Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

Giannakis, Marios; Jasmine Mu, Xinmeng; A. Shukla, Sachet; Rong Qian, Zhi; Cohen, Ofir; Nishihara, Reiko; Bahl, Samira; Cao, Yin; Amin‐Mansour, Ali; Yamauchi, Mai; Sukawa, Yasutaka; Stewart, Chip; Rosenberg, Mara; Mima, Kosuke; Inamura, Kentaro; Nosho, Katsuhiko; A. Nowak, Jonathan; S. Lawrence, Michael; L. Giovannucci, Edward; T. Chan, Andrew; Ng, Kimmie; A. Meyerhardt, Jeffrey; M. Van Allen, Eliezer; Getz, Gad; B. Gabriel, Stacey; S. Lander, Eric; J. Wu, Catherine; S. Fuchs, Charles; Ogino, Shuji; A. Garraway, Levi

doi:10.1016/j.celrep.2016.03.075

Public

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

Published in Cell Reports • Apr 1, 2016

Authors:

Marios Giannakis

Xinmeng Jasmine Mu

Sachet A. Shukla

Abstract

Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 incident colorectal cancers (CRCs) and integrated the results with tumor immunity, pathology, and survival data. We identified re...

Subject

Microsatellite instability

Colorectal cancer

Immune system

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