A Randomized Trial Comparing Fluconazole with Amphotericin B for the Treatment of Candidemia in Patients without Neutropenia

Rex, John; E. Bennett, John; M. Sugar, Alan; G. Pappas, Peter; M. van der Horst, Charles; E. Edwards, John; G. Washburn, Ronald; Michael Scheld, W.; W. Karchmer, Adolf; Dine, A.; J. Levenstein, Marcia; Webb, Charles

doi:10.1056/nejm199411173312001

Public

A Randomized Trial Comparing Fluconazole with Amphotericin B for the Treatment of Candidemia in Patients without Neutropenia

Published in New England Journal of Medicine • Nov 17, 1994

Authors:

John Rex

John E. Bennett

Alan M. Sugar

Abstract

BACKGROUND: Amphotericin B has long been the standard treatment for candidemia, but its use is complicated by its toxicity. More recently, fluconazole, a water-soluble triazole with activity against candida species and little toxicity, has become available. We conducted a multicenter randomized tria...

Subject

Fluconazole

Amphotericin B

Medicine

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