Afatinib Activity in Platinum-Refractory Metastatic Urothelial Carcinoma in Patients With ERBB Alterations

J. Choudhury, Noura; Campanile, Alexa; Antic, Tatjana; Lee Yap, Kai; Fitzpatrick, Carrie; L. Wade, James; Karrison, Theodore; M. Stadler, Walter; Nakamura, Yusuke; H. O’Donnell, Peter

doi:10.1200/jco.2015.66.3047

Public

Afatinib Activity in Platinum-Refractory Metastatic Urothelial Carcinoma in Patients With ERBB Alterations

Published in Journal of Clinical Oncology • Apr 4, 2016

Authors:

Noura J. Choudhury

Alexa Campanile

Tatjana Antic

Abstract

PURPOSE: Somatic mutations and copy number variation in the ERBB family are frequent in urothelial carcinoma (UC) and may represent viable therapeutic targets. We studied whether afatinib (an oral, irreversible inhibitor of the ErbB family) has activity in UC and if specific ERBB molecular alteratio...

Subject

Medicine

Afatinib

Internal medicine

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