Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer

Crawford, Jeffrey; Ozer, Howard; G. Stoller, Ronald; H. Johnson, David; H. Lyman, Gary; A. Tabbara, Imad; G. Kris, Mark; Grous, John; J. Picozzi, Vincent; Rausch, Gregory; E. Smith, Roy; J. Gradishar, William; M. Yahanda, Anne; Vincent, M.; E. Stewart, Morgan; A. Glaspy, John

doi:10.1056/nejm199107183250305

Public

Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer

Published in New England Journal of Medicine • Jul 18, 1991

Authors:

Jeffrey Crawford

Howard Ozer

Ronald G. Stoller

Abstract

BACKGROUND: Neutropenia and infection are major dose-limiting side effects of chemotherapy. Previous studies have suggested that recombinant methionyl granulocyte colony-stimulating factor (G-CSF) can reduce chemotherapy-related neutropenia in patients with cancer. We conducted a randomized clinical...

Subject

Medicine

Neutropenia

Granulocyte colony-stimulating factor

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