A Comparison of Budesonide with Prednisolone for Active Crohn's Disease

Rutgeerts, Paul; Löfberg, Robert; Malchow, H; B. H. W. Lamers, C.; Olaison, Gunnar; P. Jewell, Derek; Danielsson, Åke; Goebell, H.; Østergaard Thomsen, Ole; Lorenz‐Meyer, H.; Hodgson, Humphrey; Persson, Tore; Seidegard, Cecilia

doi:10.1056/nejm199409293311304

Public

A Comparison of Budesonide with Prednisolone for Active Crohn's Disease

Published in New England Journal of Medicine • Sep 29, 1994

Authors:

Paul Rutgeerts

Robert Löfberg

H Malchow

Abstract

BACKGROUND: Patients with active Crohn's disease are often treated with corticosteroids, but the treatment has many side effects. Budesonide is a potent, well-absorbed corticosteroid, but because of a high rate of first-pass metabolism in the liver, its systemic bioavailability is low. METHODS: We c...

Subject

Budesonide

Medicine

Prednisolone

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