CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

J. Turtle, Cameron; Hanafi, Laïla‐Aïcha; Berger, Carolina; A. Gooley, Theodore; Cherian, Sindhu; Hudecek, Michael; Sommermeyer, Daniel; M. Melville, Katherine; Pender, Barbara; M Budiarto, Tanya; Robinson, Emily; N Steevens, Natalia; Chaney, Colette; Soma, Lorinda; Chen, Xueyan; C.S. Yeung, Cecilia; L. Wood, Brent; Li, Daniel; Cao, Jianhong; Heimfeld, Shelly; C. Jensen, Michael; R. Riddell, Stanley; G. Maloney, David

doi:10.1172/jci85309

Public

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

Published in Journal of Clinical Investigation • Apr 24, 2016

Authors:

Cameron J. Turtle

Laïla‐Aïcha Hanafi

Carolina Berger

Abstract

BACKGROUND: T cells that have been modified to express a CD19-specific chimeric antigen receptor (CAR) have antitumor activity in B cell malignancies; however, identification of the factors that determine toxicity and efficacy of these T cells has been challenging in prior studies in which phenotypi...

Subject

CD19

CD8

Composition (language)

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