Interaction of pseudomonic acid A with Escherichia coli B isoleucyl-tRNA synthetase

Hughes, Julia; Mellows, G.

doi:10.1042/bj1910209

Public

Interaction of pseudomonic acid A with Escherichia coli B isoleucyl-tRNA synthetase

Published in Biochemical Journal • Oct 1, 1980

Authors:

Julia Hughes

G. Mellows

Abstract

Sodium pseudomonate was shown to be a powerful competitive inhibitor of Escherichia coli B isoleucyl-tRNA synthetase (Ile-tRNA synthetase). The antibiotic competitively inhibits (Ki 6 nM; cf. Km 6.3 microM), with respect top isoleucine, the formation of the enzyme . Ile approximately AMP complex as ...

Subject

Aminoacylation

Pyrophosphate

Escherichia coli

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!