Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice

Bouaziz, W.; Sigaux, Johanna; Modrowski, Dominique; Devignes, Claire-Sophie; Funck‐Brentano, Thomas; Richette, Pascal; Ea, Hang‐Korng; Provot, Sylvain; Cohen‐Solal, Martine; Haÿ, Eric

doi:10.1073/pnas.1514854113

Public

Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice

Published in Proceedings of the National Academy of Sciences • Apr 27, 2016

Authors:

W. Bouaziz

Johanna Sigaux

Dominique Modrowski

Abstract

Low oxygen tension (hypoxia) regulates chondrocyte differentiation and metabolism. Hypoxia-inducible factor 1α (HIF1α) is a crucial hypoxic factor for chondrocyte growth and survival during development. The major metalloproteinase matrix metalloproteinase 13 (MMP13) is also associated with chondrocy...

Subject

Wnt signaling pathway

TCF4

Chondrocyte

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