Reactive oxygen species, Ca2+ stores and acute pancreatitis; a step closer to therapy?

• Disruption of Ca 2+ homeostasis causes mitochondrial dysfunction and pancreatic damage. • The role of oxidative stress in acute pancreatitis (AP) is unclear. • Inhibition of acinar cell Ca 2+ overload protects mitochondria and ameliorates AP. • Prevention of MPTP formation is protective in AP. • C... View More