LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

Zheng, Jie; Mesut Erzurumluoglu, A; L Elsworth, Benjamin; P Kemp, John; Howe, Laurence; C Haycock, Philip; Hemani, Gibran; Tansey, Katherine; Laurin, Charles; Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, Early; St Pourcain, Beate; M Warrington, Nicole; K Finucane, Hilary; L Price, Alkes; K Bulik-Sullivan, Brendan; Anttila, Verneri; Paternoster, Lavinia; R Gaunt, Tom; M Evans, David; M Neale, Benjamin

doi:10.1093/bioinformatics/btw613

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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

Shared by NobleBlocks on Sep 22, 2016 • 12:00 AM UTC

Authors:

Jie Zheng

A Mesut Erzurumluoglu

Benjamin L Elsworth

Abstract

Abstract Motivation LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional categories, and estimate the genetic correl...

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