LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern

Sun, Tian-Tian; He, Jie; Liang, Qian; Ren, Lin-Lin; Yan, Ting-Ting; Yu, Ta-Chung; Tang, Jia‐Yin; Bao, Yu-Jie; Hu, Ye; Lin, Yanwei; Sun, Danfeng; Chen, Yingxuan; Hong, Jie; Chen, Haoyan; Zou, Weiping; Fang, Jing‐Yuan

doi:10.1158/2159-8290.cd-15-0921

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LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern

Published in Cancer Discovery • May 5, 2016

Authors:

Tian-Tian Sun

Jie He

Qian Liang

Abstract

UNLABELLED: Long noncoding RNAs (lncRNA) play a role in carcinogenesis. However, the function of lncRNAs in human gastric cancer remains largely unknown. In this study, we identified a novel lncRNA, GClnc1, which was upregulated and associated with tumorigenesis, tumor size, metastasis, and poor pro...

Subject

Cancer research

Cancer

Biology

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