Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein

Pande, Kanupriya; Hutchison, C.; Groenhof, Gerrit; Aquila, Andy; S. Robinson, Josef; Tenboer, Jason; Basu, Shibom; Boutet, Sébastien; P. DePonte, Daniel; Liang, Mengning; A. White, Thomas; A. Zatsepin, Nadia; Yefanov, Oleksandr; Morozov, Dmitry; Oberthüer, D.; Gati, Cornelius; Subramanian, Ganesh; James, Daniel; Zhao, Yun; D. Koralek, J.; Brayshaw, Jennifer; Kupitz, Christopher; E. Conrad, Chelsie; Roy-Chowdhury, Shatabdi; Coe, Jesse; Metz, Markus; Lourdu Xavier, P.; D. Grant, Thomas; E. Koglin, Jason; Ketawala, Gihan; Fromme, Raimund; Šrajer, V.; Henning, Robert; C. H. Spence, John; Ourmazd, A.; Schwander, Peter; Weierstall, Uwe; Frank, Matthias; Fromme, Petra; Barty, Anton; N. Chapman, Henry; Moffat, Keith; J. van Thor, Jasper; Schmidt, Marius

doi:10.1126/science.aad5081

Public

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein

Published in Science • May 5, 2016

Authors:

Kanupriya Pande

C. Hutchison

Gerrit Groenhof

Abstract

A variety of organisms have evolved mechanisms to detect and respond to light, in which the response is mediated by protein structural changes after photon absorption. The initial step is often the photoisomerization of a conjugated chromophore. Isomerization occurs on ultrafast time scales and is s...

Subject

Chromophore

Isomerization

Femtosecond

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