Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive‐stage small cell lung cancer: A trial of the ECOG‐ACRIN Cancer Research Group (E1508)

P. Belani, Chandra; E. Dahlberg, Suzanne; M. Rudin, Charles; Fleisher, Martin; X. Chen, Helen; Takebe, Naoko; R. Velasco, Mario; Tester, William; Sturtz, Keren; L. Hann, Christine; C. Shanks, James; Monga, Manish; S. Ramalingam, Suresh; H. Schiller, Joan

doi:10.1002/cncr.30062

Public

Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive‐stage small cell lung cancer: A trial of the ECOG‐ACRIN Cancer Research Group (E1508)

Published in Cancer • May 10, 2016

Authors:

Chandra P. Belani

Suzanne E. Dahlberg

Charles M. Rudin

Abstract

BACKGROUND: Preclinical targeting of the hedgehog pathway by vismodegib and of insulin-like growth factor 1 receptor by cixutumumab enhances the efficacy of chemotherapy and also demonstrates activity against the tumor cell fraction responsible for disease recurrence in small cell lung cancer. METHO...

Subject

Medicine

Vismodegib

Stage (stratigraphy)

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