Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke

S. Anderson, Craig; Robinson, Thompson; I. Lindley, Richard; Arima, Hisatomi; M. Lavados, Pablo; Lee, Tsong‐Hai; P. Broderick, Joseph; Chen, Xiaoying; Chen, Guofang; K. Sharma, Vijay; S. Kim, Jong; H. Thang, Nguyen; Cao, Yongjun; Parsons, Mark; Levi, Christopher; Huang, Yining; V. Olavarría, Verónica; M. Demchuk, Andrew; M. Bath, Philip; A. Donnan, Geoffrey; Cristina Ouriques Martins, Sheila; Marques Pontes‐Neto, Octávio; Silva, Federico; Ricci, Stefano; Roffe, Christine; Pandian, Jeyaraj; Billot, Laurent; Woodward, Mark; Li, Qiang; Wang, Xia; Wang, Ji‐Guang; Chalmers, John

doi:10.1056/nejmoa1515510

Public

Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke

Published in New England Journal of Medicine • May 10, 2016

Authors:

Craig S. Anderson

Thompson Robinson

Richard I. Lindley

Abstract

BACKGROUND: Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravenous alteplase may improve recovery along with a reduced risk of intracerebral hemorrhage. METHODS: Using a 2-by-2 quasi-factorial open-label design, we randomly assigned 3310 patients who were eligi...

Subject

Medicine

Intracerebral hemorrhage

Modified Rankin Scale

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