Batch‐ and Continuous‐Flow Aerobic Oxidation of 14‐Hydroxy Opioids to 1,3‐Oxazolidines—A Concise Synthesis of Noroxymorphone

Gutmann, Bernhard; Weigl, Ulrich; Phillip Cox, D.; Oliver Kappe, C.

doi:10.1002/chem.201601902

Public

Batch‐ and Continuous‐Flow Aerobic Oxidation of 14‐Hydroxy Opioids to 1,3‐Oxazolidines—A Concise Synthesis of Noroxymorphone

Published in Chemistry - A European Journal • May 12, 2016

Authors:

Bernhard Gutmann

Ulrich Weigl

D. Phillip Cox

Abstract

14-Hydroxymorphinone is converted to noroxymorphone, the immediate precursor of important opioid antagonists, such as naltrexone and naloxone, in a three-step reaction sequence. The initial oxidation of the N-methyl group in 14-hydroxymorphinone with in situ generated colloidal palladium(0) as the c...

Subject

Oxazolidine

Chemistry

Catalysis

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