Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens.

M, Senni; JJ, McMurray; R, Wachter; HF, McIntyre; A, Reyes; I, Majercak; P, Andreka; N, Shehova-Yankova; I, Anand; MB, Yilmaz; H, Gogia; M, Martinez-Selles; S, Fischer; Z, Zilahi; F, Cosmi; V, Gelev; E, Galve; JJ, Gómez-Doblas; J, Nociar; M, Radomska; B, Sokolova; M, Volterrani; A, Sarkar; B, Reimund; F, Chen; A, Charney

doi:10.1002/ejhf.548

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Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens.

Shared by NobleBlocks on May 12, 2016 • 12:00 AM UTC

Authors:

Senni M

McMurray JJ

Wachter R

Abstract

Aims To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ≤35%).Methods and results A 5-day open-label run-in (sacubitril/valsartan 50 mg twice daily) preced...

Subject

valsartan

Heart Failure

Tolerability

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