Initiating Sacubitril/Valsartan (LCZ696) in Heart Failure: Results of TITRATION, a Double-Blind, Randomized Comparison of Two Uptitration Regimens

Senni, Michele; J.V. McMurray, John; Wachter, Rolf; McIntyre, Hugh; Reyes, Antonio; Majerčák, Ivan; Andréka, Péter; S Shehova-Yankova, Nina; S. Anand, Inder; Birhan Yılmaz, Mehmet; Gogia, Harinder; Martínez‐Sellés, Manuel; Fischer, Steffen; Zilahi, Z; Cosmi, Franco; Гелев, Валери; Galve, Enrique; J. Gómez‐Doblas, Juanjo; Nociar, Jan; Radomska, M.; Sokolova, Beata; Volterrani, Maurizio; Sarkar, Arnab; Reimund, Bernard; Chen, Fabian; Charney, Alan

doi:10.1002/ejhf.548

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Initiating Sacubitril/Valsartan (LCZ696) in Heart Failure: Results of TITRATION, a Double-Blind, Randomized Comparison of Two Uptitration Regimens

Published in European Journal of Heart Failure • May 12, 2016

Authors:

Michele Senni

John J.V. McMurray

Rolf Wachter

Abstract

AIMS: To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ≤35%). METHODS AND RESULTS: A 5-day open-label run-in (sacubitril/valsartan 50 mg twice daily) pre...

Subject

Medicine

Tolerability

Sacubitril

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