Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

Wang, Xiaoming; L. Bey, Alexandra; M. Katz, Brittany; Badea, Alexandra; Kim, Namsoo; K. David, Lisa; J. Duffney, Lara; Kumar, Sunil; D. Mague, Stephen; W. Hulbert, Samuel; Dutta, Nisha; Hayrapetyan, Volodya; Yu, Chunxiu; Gaidis, Erin; Zhao, Shengli; Ding, Jindong; Xu, Qiong; Chung, Leeyup; M. Rodriguiz, Ramona; Wang, Fan; J. Weinberg, Richard; C. Wetsel, William; Dzirasa, Kafui; H. Yin, Henry; Jiang, Yong-Hui

doi:10.1038/ncomms11459

Public

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

Published in Nature Communications • May 10, 2016

Authors:

Xiaoming Wang

Alexandra L. Bey

Brittany M. Katz

Abstract

Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of the autism-associated Shank3 g...

Subject

Neuroscience

Autism

Biological neural network

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