Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

Lü, Chao; U. Jain, Siddhant; Hoelper, Dominik; Béchet, Denise; C. Molden, Rosalynn; Ran, Leili; Murphy, Devan; Venneti, Sriram; Hameed, Meera; Pawel, Bruce; S. Wunder, Jay; C. Dickson, Brendan; Lundgren, Stefan; S. Jani, Krupa; Jay, Nicolas; Papillon‐Cavanagh, Simon; L. Andrulis, Irene; L. Sawyer, Sarah; Grynspan, David; Turcotte, Robert; Nadaf, Javad; Fahiminiyah, Somayyeh; W. Muir, Tom; Majewski, Jacek; B. Thompson, Craig; Chi, Ping; A. Garcia, Benjamin; David Allis, C.; Jabado, Nada; W. Lewis, Peter

doi:10.1126/science.aac7272

Public

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

Published in Science • May 12, 2016

Authors:

Chao Lü

Siddhant U. Jain

Dominik Hoelper

Abstract

Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we report that the H3 lysine 36-to-methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells...

Subject

Histone

Histone methylation

Chromatin

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